Hyaluronidase Skin Spreading Effect

The Relationship between Spreading Factor and Hyaluronidase

A comparative study of spreading factor and hyaluronidase in preparations from various sources revealed the following points of similarity and dissimilarity in the two reactions. 1. Similarities: (a) All preparations containing hyaluronidase also produced spreading. (b) Heating at 65 degrees and 100 degrees C. for 30 minutes produced a comparable effect on both reactions. (c) The demonstration ...

Influence of Morphine on Tissue Permeability and the Spreading Effect of Hyaluronidase *

Work recently reviewed by Duran-Reynals,6 in whose laboratory this investigation was carried out, has provided facts which form the basis for a concept of the permeability of connective tissue. Tissue permeability has a normal constitutional state or tonus which can be increased by certain factors and decreased by others. Of the former, the most important are the spreading factors, some of whic...

Studies on Spreading Factors I. the Importance of Mechanical Factors in Hyaluronidase Action in Skin* by Oscar

I t is generally agreed that there is a close relationship between spreading factors (S. F.) from testis, bacteria, venoms, and other sources with the mucolyric enzyme, hyaluronidase (cf. the review of Duran-Reynals (1) for references). While it is known that hyaluronidase removes a dermal barrier (presumably hyaluronic acid) to the diffusion of fluids in skin certain aspects of hyaluronidase s...

Anti-histamine effect of sodium salicylate and its bearing upon the skin-diffusing activity of hyaluronidase.

Hyaluronidase activity in the skin, rheumatic disease, and salicylates.

This study* was undertaken to ascertain the effect of salicylate on the spreading activity of testicular extract (T.E.) in the human skin, and its relationship to rheumatic disease. Introduction Hyaluronidase.-It was shown by Duran-Reynals (1928) and McClean (1930) that testicular extract would enhance the infection by vaccinia virus. DuranReynals (Hoffman and Duran-Reynals, 1930) further noted...